Description
Description: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
Source: Genetically modified E.coli.
Predicted MW: Monomer, 12.7 kDa (with 110 amino acids)
AA Sequence: MHKCDITLQE IIKTLNILTA RKNSCMELPV TDVFAAPENT TEKETFCRAS TVLRHIYRHH TCMKSLLSGL DRNLSSMANM TCSVHEAKKS TLKDFLERLK TIMKEKYSKC
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA.
Specification |
Method of Determination |
Acceptance Criteria |
Purity |
Reducing and Non-Reducing SDS-PAGE |
≥95% |
Endotoxin |
Kinetic LAL (50% confidence) |
≤ 1 EUs/µg |
Biological Activity |
TF-1 cell proliferation |
ED50 ≤ 2 ng/mL |
Preparation and Storage
Country of Origin: USA Shipping: Room temperature
Storage Prior to Reconstitution: -20°C
Product Reconstitution: Sterile water at 0.1 mg/mL
Instructions: Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.
Expiration Date
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.
THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!
To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.
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