Description
Alternate Names: Megakaryocyte Colony Stimulating Factor, c-MPL Ligand, MGDF Accession Number: P40226
Description: Thrombopoietin (TPO) is a growth factor that is produced by liver and kidney tissues. TPO binds the TPO receptor (CD110) to promote megakaryocyte maturation, differentiation, and the production of platelets.
Source: Genetically modified E.coli.
Predicted MW: Monomer, 18.7 kDa (175 aa)
AA Sequence: MSPVAPACDP RLLNKLLRDS HLLHSRLSQC PDVDPLSIPV LLPAVDFSLG EWKTQTEQSK AQDILGAVSL LLEGVMAARG QLEPSCLSSL LGQLSGQVRL LLGALQGLLG TQLPLQGRTT AHKDPNALFL SLQQLLRGKV RFLLLVEGPT LCVRRTLPTT AVPSSTSQLL TLNKF
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.
Specification |
Method of Determination |
Acceptance Criteria |
Purity |
Reducing and Non-Reducing SDS PAGE |
≥95% |
Endotoxin |
Kinetic LAL |
≤1 EUs/µg |
Biological Activity |
MO7e cell proliferation |
≤5 ng/mL |
Country of Origin: USA Shipping: Room temperature
Product Reconstitution: Sterile water at 0.1 mg/mL
Instructions: Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.
Expiration Date
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.
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