Mouse MIP-1 beta / CCL4

Mouse MIP-1 beta / CCL4

Part Number: 200-43

Macrophage inflammatory protein-1 beta (MIP-1 Ž²), also known as CCL4, is ‚ produced by macrophages and functions as a mitogen-inducible cytokine. ‚ MIP-1 Ž² signals through the chemokine receptor CCR5 to chemoattract immune cells. ‚ MIP-1 Ž² induces inflammatory responses, including neutrophil superoxide production. ‚ The MIP-1 Ž² and MIP-1 Ž± heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).

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Description

Alternate Names:  CCL4, ACT-2               Accession Number: Q5QNV9
Description:  Macrophage inflammatory protein-1 beta (MIP-1 β), also known as CCL4, is  produced by macrophages and functions as a mitogen-inducible cytokine.  MIP-1 β signals through the chemokine receptor CCR5 to chemoattract immune cells.  MIP-1 β induces inflammatory responses, including neutrophil superoxide production.  The MIP-1 β and MIP-1 α heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1). 
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 7.8 kDa (69 aa)
AA Sequence:  APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤1 EUs/µg

Biological Activity

THP-1 chemotaxis

≤100 ng/mL 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
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Mg: 1, Midgi: 500 ug, Mini: 2 ug, Std.: 10 ug, Value: 100 ug

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