Description

Alternate Names:  IL-17, CTLA-8               Accession Number: Q62386
Description:  Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins.  IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes.  IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion.  In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.  Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.  Human, mouse, and rat IL-17A show activity on mouse cells.  
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 15.1/30.2 kDa (134/268 aa)
AA Sequence:  MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Expiration Date                      
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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