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Part Number: 200-25
Interleukin 12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naƒ¯ve T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon gamma (IFN-Ž³) and tumor necrosis factor alpha (TNF-Ž±) from T cells and natural killer cells. Mouse IL-12 is active on human and mouse cells.
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$67.00 – $8,021.00
Alternate Names: NKSF, CLMF Accession Number: P43432/P43431
Description: Interleukin 12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naïve T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) from T cells and natural killer cells. Mouse IL-12 is active on human and mouse cells.
Source: Genetically modified HEK 293 cells.
Predicted MW: Heterodimer, p35: 21.7 kDa, p40: 35.8 kDa, total: 57.5 kDa (p35: 193 aa, p40: 313 aa, total: 506 aa)
AA Sequence: p35: RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV VTINRVMGYL SSA
p40: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.
|
Specification |
Method of Determination |
Acceptance Criteria |
|
Purity |
Reducing and Non-Reducing SDS PAGE |
≥95% |
|
Endotoxin |
Kinetic LAL |
≤1 EUs/µg |
|
Biological Activity |
Induction of SEAP in HEK-Blue™ IL-12 cells |
≤ 20 ng/mL; ≥ 5.0 x 10^4 units/mg
|
Preparation and Storage
Country of Origin: USA Shipping: Room temperature
Expiration Date
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.
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Part Number: Other Terms:
| Dimensions | 1 × 1 × 1 cm |
|---|---|
| Select size | Mg: 1 mg, Midgi: 500 ug, Mini: 2 ug, Std.: 10 ug, Value: 100 ug |
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