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Mouse EBI3 Subunit (IL-27 / IL-35)

Mouse EBI3 Subunit (IL-27 / IL-35)

Part Number: 200-57

Epstein-Barr virus induced gene 3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). ‚ EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection.‚EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35).‚Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.

 

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Description

Alternate Names:  IL-35/EBI3, IL-27 EBI3 subunit, IL-35 EBI3 subunit
Accession Number: O35228
Description:  Epstein-Barr virus induced gene 3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12).  EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection.  EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35).  Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 23 kDa (207 aa)
AA Sequence:  MALVALSQPR VQCHASRYPV AVDCSWTPLQ APNSTRSTSF IATYRLGVAT QQQSQPCLQR SPQASRCTIP DVHLFSTVPY MLNVTAVHPG GASSSLLAFV AERIIKPDPP EGVRLRTAGQ RLQVLWHPPA SWPFPDIFSL KYRLRYRRRG ASHFRQVGPI EATTFTLRNS KPHAKYCIQV SAQDLTDYGK PSDWSLPGQV ESAPHKP
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥90%
Endotoxin Kinetic LAL ≤1 EUs/µg
Biological Activity No biological activity data is available at this time No biological activity data is available at this time
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 20 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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Additional information

Dimensions 1 × 1 × 1 cm
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Mg: 1 mg, Midgi: 500 ug, Mini: 2 ug, Std.: 10 ug, Value: 100 ug

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