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Human/Mouse/Rat Activin A

Human/Mouse/Rat Activin A

Part Number: 800-01

Activin A is a member of the transforming growth factor beta (TGF-Ž²) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion. ‚ Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. ‚ Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation,

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Description

Catalog Numbers: 800-01 is a replacement number for Human 100-43 / Mouse 200-29 / Rat 300-06 (100% sequence identity)

Alternate Names:  Inhibin beta-1, FRP, FSH-releasing protein

Accession Number: P08476
Description:  Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin βA chains.  Cleavage of the N-terminal propeptide renders the Activin protein biologically active.  Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.
Source:  Genetically modified E.coli.
Predicted MW: Dimer, 13.1/26.2 kDa (117/234 aa)
AA Sequence:  MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥95%
Endotoxin Kinetic LAL ≤1 EUs/µg
Biological Activity Cytotoxicity of MPC-11 cells ≤10 ng/mL

  **** International Units: The specific activity of Human/Mouse/Rat Activin A is approximately 1.2 IU/μg, which is calibrated against recombinant human Activin A WHO International Standard (NIBSC code: 91/626).

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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Additional information

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Animal-Free Mg: 1 mg, Animal-Free Midgi: 500 ug, Animal-Free Mini: 2 ug, Animal-Free Std.: 10 ug, Animal-Free Value: 100 ug, Mg: 1 mg, Midgi: 500 ug, Mini: 2 ug, Std.: 10 ug, Value: 100 ug

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