Th9 cells are a unique subset of T helper cells that produce IL-9. Although the exact function of IL-9 producing T cells is yet to be completely clear it is proposed that these cells could be important in inflammation and helminth infections. Th9 cells can be generated from naive CD4+ T cells in culture by culturing them in the presence of IL-4 (at 10-20 ng/mL) and TGF-beta 1 (1-5 ng/mL). It also appears that IFNy and IL-27 can inhibit the generation of Th9 cells.
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