Catalog Number: 800-05 is a replacement for Human 100-182 / mouse 200-73 (100% sequence identity)
Alternate Names:‚HHG-2‚‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚Accession Number: Q14623
Description:‚Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.
Source:‚Genetically modified E.coli.
Predicted MW:‚ Monomer, 19.9 kDa (177 aa)
AA Sequence:‚MIIGPGRVVG‚ SRRRPPRKLV‚ PLAYKQFSPN‚ VPEKTLGASG‚ RYEGKIARSS‚ ERFKELTPNY‚ NPDIIFKDEE‚ NTGADRLMTQRCKDRLNSLA‚ ISVMNQWPGV‚ KLRVTEGWDE‚ DGHHSEESLH‚ YEGRAVDITT‚ SDRDRNKYGL‚ LARLAVEAGF‚ DWVYYESKAH‚ VHCSVKSEHSAAAKTGG
Formulation:‚Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.‚The values provided here are minimum expected values to pass internal requirements.‚
|Specification||Method of Determination||Acceptance Criteria|
|Purity||Reducing and Non-Reducing SDS PAGE||¢€°¥95%|
|Endotoxin||Kinetic LAL||¢€°¤1 EUs/‚µg|
|Biological Activity||No biological activity data is available at this time||No biological activity data is available at this time|
Preparation and Storage
Country of Origin:‚USA ‚ ‚ ‚ ‚ ‚ ‚Shipping:‚Room temperature
Storage Prior to Reconstitution:‚-20‚°C
Product Reconstitution:‚10 mM HCl at 0.1 mg/mL
Instructions:‚Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80‚°C and avoid repeat freeze thaws.
12 months from date of receipt when stored at -20‚°C to -80‚°C as supplied.
1 month when stored at 4‚°C after reconstituting as directed.
3 months when stored at -20‚°C to -80‚°C after reconstituting as directed.
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