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Part Number: 100-220
Interleukin 34 (IL-34) was originally identified in humans, by large scale screening of secreted proteins; orthologs have also been found‚in chimpanzee, murine, rat and chicken. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. IL-34 is secreted as a homodimer and contains one potential N-glycosylation site.‚IL-34 increases proliferation of immune cells known as monocytes; it elicits its activity by binding the Colony Stimulating Factor 1 Receptor (CSF-1R). Expression of IL-34 is most abundant in the spleen and is expressed in many other tissues including the heart, brain, liver, kidney, thymus, intestine and lung.
[bulk_variations include=”6743″]
$184.00
Alternate Names:None Accession Number: NP_689669
Description:Interleukin 34 (IL-34) was originally identified in humans, by large scale screening of secreted proteins; orthologs have also been found in chimpanzee, murine, rat and chicken. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. IL-34 is secreted as a homodimer and contains one potential N-glycosylation site. IL-34 increases proliferation of immune cells known as monocytes; it elicits its activity by binding the Colony Stimulating Factor 1 Receptor (CSF-1R). Expression of IL-34 is most abundant in the spleen and is expressed in many other tissues including the heart, brain, liver, kidney, thymus, intestine and lung. Human IL-34 contains a C-terminal 6x-polyhistidine (6xHis) tag.
Source:Genetically modified CHO cells.
Predicted MW: Dimer, 26 kDa (228 amino acids)
AA Sequence:NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRLQRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSPKVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCSPEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHH
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing phosphate buffered saline (PBS)
Product Specifications
| Specification | Method of Determination | Acceptance Criteria | Result |
| Purity | Reducing and Non-Reducing SDS-PAGE | ‰¥95% | ‰¥95% |
| Endotoxin | Kinetic LAL (50% confidence) | ‰¤1 EUs/µg | <0.050 EUs/ug |
Product Reconstitution:Sterile water at 0.1 mg/mL
Expiration Date:
13 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.
THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!
Part Number: Other Terms:
| Weight | 1 g |
|---|---|
| Select size | Mg: 1mg, Mini: 10 ug, Std: 100ug, Value: 500ug |
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