Human IL-34

Human IL-34

Part Number: 100-220

Interleukin 34 (IL-34) was originally identified in humans, by large scale screening of secreted proteins; orthologs have also been found‚in chimpanzee, murine, rat and chicken. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. IL-34 is secreted as a homodimer and contains one potential N-glycosylation site.‚IL-34 increases proliferation of immune cells known as monocytes; it elicits its activity by binding the Colony Stimulating Factor 1 Receptor (CSF-1R). Expression of IL-34 is most abundant in the spleen and is expressed in many other tissues including the heart, brain, liver, kidney, thymus, intestine and lung.

[bulk_variations include=”6743″]

$184.00

Clear

Description

Alternate Names:None Accession Number: NP_689669

Description:Interleukin 34 (IL-34) was originally identified in humans, by large scale screening of secreted proteins; orthologs have also been found in chimpanzee, murine, rat and chicken. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. IL-34 is secreted as a homodimer and contains one potential N-glycosylation site. IL-34 increases proliferation of immune cells known as monocytes; it elicits its activity by binding the Colony Stimulating Factor 1 Receptor (CSF-1R). Expression of IL-34 is most abundant in the spleen and is expressed in many other tissues including the heart, brain, liver, kidney, thymus, intestine and lung. Human IL-34 contains a C-terminal 6x-polyhistidine (6xHis) tag.

Source:Genetically modified CHO cells.

Predicted MW: Dimer, 26 kDa (228 amino acids)

AA Sequence:NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRLQRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSPKVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCSPEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHH

Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing phosphate buffered saline (PBS)

Product Specifications

Specification Method of Determination Acceptance Criteria Result
Purity Reducing and Non-Reducing SDS-PAGE ‰¥95% ‰¥95%
Endotoxin Kinetic LAL (50% confidence) ‰¤1 EUs/µg <0.050 EUs/ug
Preparation and Storage

Country of Origin:USA      Shipping:Room temperature

Storage Prior to Reconstitution:-20°C

Product Reconstitution:Sterile water at 0.1 mg/mL

Instructions:Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:

13 months from date of receipt when stored at -20°C to-80°C as supplied.

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!

Part Number: Other Terms:

Additional information

Weight 1 g
Select size

Mg: 1mg, Mini: 10 ug, Std: 100ug, Value: 500ug

Reviews

There are no reviews yet.

Be the first to review “Human IL-34”

Your email address will not be published.