Human IL-1RA / IL-1F3

Human IL-1RA / IL-1F3

Part Number: 100-195

Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling.‚IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation.‚IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.‚ 

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Description

Alternate Names:  IL1RN, IL-1F3                    Accession Number: P18510    
Description:  Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling.  IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation.  IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis. 
Source:  Genetically modified E.coli
Predicted MW:  17.3 kDa (with 153 amino acids)
AA Sequence:  MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS-PAGE

≥ 95%

Endotoxin

Kinetic LAL (50% confidence)

≤ 1 EUs/µg

Biological Activity

Inhibition of human IL-1 alpha induced proliferation of D10.G4.1 cells

ED50 ≤ 50 ng/mL


Preparation and Storage

Country of Origin:  USA         Shipping:  Room temperature              

Storage Prior to Reconstitution:  -20°C

Product Reconstitution:  Sterile water at 0.1 mg/mL    

Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.   


Expiration Date:                      

12 months from date of receipt when stored at -20°C to-80°C as supplied. 

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

                                                                                   

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!           

 

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Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
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Animal-Free Mg: 1 mg, Animal-Free Midig: 500 ug, Animal-Free Mini: 20 ug, Animal-Free Std.: 100 ug, Animal-Free Value: 250 ug, Mg: 1 mg, Midig: 500 ug, Mini: 20 ug, Std.: 100 ug, Value: 250 ug

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