Description

Alternate Names:  NC30              

Accession Number: P35225
Description:  Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells.  IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression.  IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells.  The IL-13 receptor consists of the IL-4Ra and IL-13Ra1 subunits.  IL-13 can also bind the IL-13Ra2 receptor with high affinity.  IL-13 functions are mediated through the JAK/STAT signaling pathway.  Human and mouse IL-13 are cross-reactive.  
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 12.6 kDa (115 aa)
AA Sequence:  MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Expiration Date                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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