Human IFN-gamma

Human IFN-gamma

Part Number: 100-77

Interferon gamma (IFN-Ž³) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-Ž³ is produced by T cells and natural killer cells following antigen-specific activation. IFN-Ž³ binds IFN-Ž³ receptors (IFN-Ž³ R1 and IFN-Ž³ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-Ž³-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFN-Ž³ is not cross-reactive with mouse IFN-Ž³.

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Description

Alternate Names:  Type II interferon, T cell interferon, Immune Interferon, MAF               Accession Number: P01579
Description:  Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFN-γ is not cross-reactive with mouse IFN-γ.
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 16.9 kDa (144 aa)
AA Sequence:  MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥95%

Endotoxin

Kinetic LAL

≤ 1 EUs/ug

Biological Activity

Activity of HEK-Blue™ IFN-γ Cells

≤ 0.7 ng/mL; ≥ 1.4 x 10^6 units/mg

 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. If a precipitate is observed, centrifuge the solution thoroughly and use only the soluble fraction (removing it from the precipitate). A 10% overfill has been added to compensate for any loss of protein in the precipitate. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

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Additional information

Dimensions 1 × 1 × 1 cm
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Animal-Free Mg: 1 mg, Animal-Free Midgi: 500 ug, Animal-Free Mini: 20 ug, Animal-Free Std.: 100 ug, Animal-Free Value: 250 ug, Mg: 1 mg, Midgi: 500 ug, Mini: 20 ug, Std.: 100 ug, Value: 250 ug

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