Alternate Names:Keratinocyte growth factor 2,Accession Number: O15520
Description:Fibroblast growth factor 10 (FGF-10) is a growth factor that is important during embryonic development, especially during lung, limb, brain, heart, and kidney morphogenesis. FGF-10 is expressed in mesenchymal cells and facilitates epithelial-mesenchymal signaling through binding the epithelially expressed FGF receptor 2b (FGFR2b). FGF-10 also functions as a mitogen for keratinizing epidermal cells, and induces the migration and invasion of cancer cells.
Source:Genetically modified E.coli.
Predicted MW: Monomer, 19.3 kDa (170 aa)
AA Sequence:MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEIGVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS
Formulation:Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.The values provided here are minimum expected values to pass internal requirements.
|Specification||Method of Determination||Acceptance Criteria|
|Purity||Reducing and Non-Reducing SDS PAGE||‰¥95%|
|Endotoxin||Kinetic LAL||‰¤1 EUs/µg|
|Biological Activity||4MBr-5 cell proliferation||‰¤200 ng/mL; ‰¥ 5.0 x 10^3 units/mg|
Preparation and Storage
Country of Origin:USA Shipping:Room temperature
Storage Prior to Reconstitution:-20°C
Product Reconstitution:Sterile water at 0.1 mg/mL
Instructions:Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.
12 months from date of receipt when stored at -20°C to-80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.
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Part Number: Other Terms: FGF10, KGF2