Description

Alternate Names:  IL-35/EBI3, IL-27/EBI3               Accession Number: Q14213
Description:  Epstein-Barr virus induced gene-3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12).  EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection.  EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35).  Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.     
Source:  Genetically modified E.coli.
Predicted MW: Monomer, 23.4 kDa (210 aa)
AA Sequence:  MRKGPPAALT LPRVQCRASR YPIAVDCSWT LPPAPNSTSP VSFIATYRLG MAARGHSWPC LQQTPTSTSC TITDVQLFSM APYVLNVTAV HPWGSSSSFV PFITEHIIKP DPPEGVRLSP LAERQLQVQW EPPGSWPFPE IFSLKYWIRY KRQGAARFHR VGPIEATSFI LRAVRPRARY YVQVAAQDLT DYGELSDWSL PATATMSLGK
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) + 0.5% mannitol

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             

Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile 10 mM HCl at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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Part Number: Other Terms: EB13, IL27, IL35