Human BMPR-1A / ALK-3, Fc Tag

Human BMPR-1A / ALK-3, Fc Tag

Part Number: 100-214

Bone morphogenetic protein receptor type-1A (BMPR-1A) is a Type I receptor that complexes with BMP Type II receptors to activate SMAD signaling.‚BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6.‚This protein product contains the first 152 amino acids of the extracellular portion of BMPR-1A and can be used to interfere with or neutralize ligand signaling.‚The product contains a C-terminus linker (IEGRMD) and an Fc tag (Human IgG1).‚ 

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Description

Alternate Names:  BMP type-1A receptor, Activin receptor-like kinase 3, SKR5, Serine/threonine-protein kinase receptor R5, CD292, BRK€‘1                       
Accession Number: P36894    
Description:  Bone morphogenetic protein receptor type-1A (BMPR-1A) is a Type I receptor that complexes with BMP Type II receptors to activate SMAD signaling.  BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6.  This protein product contains the first 152 amino acids of the extracellular portion of BMPR-1A and can be used to interfere with or neutralize ligand signaling.  The product contains a C-terminus linker (IEGRMD) and an Fc tag (Human IgG1). 
Source:  Genetically modified CHO cells.
Predicted MW:  Dimer, 40.4/80.8 kDa (with 362/724 amino acids)
AA Sequence:  QNLDSMLHGT GMKSDSDQKK SENGVTLAPE DTLPFLKCYC SGHCPDDAIN NTCITNGHCF AIIEEDDQGE TTLASGCMKY EGSDFQCKDS PKAQLRRTIE CCRTNLCNQY LQPTLPPVVI GPFFDGSIRI EGRMDDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing PBS

Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS-PAGE

>95%

Endotoxin

Kinetic LAL (50% confidence)

≤1 EUs/µg

Biological Activity

Inhibition of human BMP-4-induced alkaline phosphatase production by ATDC5 cells

ED50≤ 120 ng/mL

Preparation and Storage

Country of Origin:  USA         Shipping:  Room temperature              

Storage Prior to Reconstitution:  -20°C

Product Reconstitution:  Sterile water at 0.1 mg/mL    

Instructions:      Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws. 


Expiration Date:                      

12 months from date of receipt when stored at -20°C to-80°C as supplied. 

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

                                                                                   

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!           

 

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Mg: 1 mg, Midgi: 500 ug, Mini: 5 ug, Std.: 20 ug, Value: 100 ug

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