Human BMP-4

Human BMP-4

Part Number: 100-212

Bone morphogenetic protein‚ 4‚ (BMP-4) is a member of the bone morphogenetic sub-family (BMP) and functions as a critical element involved in the culture and differentiation of stem cells.‚ 

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Description

Alternate Names:  BMP-2B                 Accession Number: P12644     
Description:  Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic sub-family (BMP) and functions as a critical element involved in the culture and differentiation of stem cells.  Active BMP-4 consists of forming a homodimer or a heterodimer with related BMPs, such as BMP-7. BMP-4 is integral in stem cell cultures and the differentiation of mesoderm and ectoderm from pluripotent stem cells (iPSCs and ESCs).  BMP-4 is used in protocols for culturing cardiomyocytes, early hematopoietic cells, hepatocytes, bone, cartilage, adipocytes and lung, as well as, inhibition of early neuronal differentiation.
Source:  Genetically modified CHO cells. 
Predicted MW:  Dimer, 13.1/26.2 kDa (with 116/232 amino acids)
AA Sequence:  SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS-PAGE

≥95%

Endotoxin

Kinetic LAL (50% confidence)

≤1 EUs/µg

Biological Activity

Alkaline phosphatase activity induced in ATDC-5 cells

ED50 ≤15 ng/mL 

 

Preparation and Storage

Country of Origin:  USA         Shipping:  Room temperature              

Storage Prior to Reconstitution:  -20°C

Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws.   


Expiration Date                       

12 months from date of receipt when stored at -20°C to-80°C as supplied. 

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

                                                                                   

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

 

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Mg: 1 mg, Midgi: 500 ug, Mini: 5 ug, Std.: 20 ug, Value: 100 ug

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