Alternate Names: None Accession Number: P23560
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival. BDNF expression in the hippocampus is essential for long-term memory storage and learning. Human, mouse, rat, and pig BDNF are cross-reactive.
Source: Genetically modified E.coli.
Predicted MW: Noncovalent Homodimer, 13.6/27.3 kDa (120/240 aa)
AA Sequence: MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.
|Specification||Method of Determination||Acceptance Criteria|
|Purity||Reducing and Non-Reducing SDS PAGE||≥95%|
|Endotoxin||Kinetic LAL||≤1 EUs/µg|
|Biological Activity||C6 cell proliferation||≤2 ug/mL; ≥ 5.0 x 102 units/mg|
Preparation and Storage
- 12 months from date of receipt when stored at -20°C to-80°C as supplied.
- 1 month when stored at 4°C after reconstituting as directed.
- 3 months when stored at -20°C to -80°C after reconstituting as directed.
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Part Number: Other Terms: BDNF