Human Apo-E4

Human Apo-E4

Part Number: 100-199

THIS PRODUCT HAS BEEN DISCONTINUED.

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Apolipoprotein E (APO-E) is a chylomicron lipoprotein that is necessary for the metabolism of lipoproteins and lipid transport.‚The APO-E gene has three alleles, termed APO-E2, APO-E3, and APO-E4.‚The APO-E allelic proteins differ by only one or two amino acids, but have different biological structures and functions.

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Description

Alternate Names:  Apolipoprotein E, Apo-E                                

Accession/Uniprot Number: P02649 VAR_000652           
Description: 
Apolipoprotein E (APO-E) is a chylomicron lipoprotein that is necessary for the metabolism of lipoproteins and lipid transport.  The APO-E gene has three alleles, termed APO-E2, APO-E3, and APO-E4.  The APO-E allelic proteins differ by only one or two amino acids, but have different biological structures and functions.  APO-E3 is the most common and neutral allele.  The APO-E4 allele is associated with an increased risk for Alzheimer’s Disease (AD) and coronary artery disease (CAD).  The APO-E4 protein morphology decreases the ability of APO-E4 to clear beta-amyloid protein from the brain, resulting in AD progression.  The APO-E2 allele is associated with type III hyperlipoproteinemia, which is characterized by defects in the clearance of plasma lipoproteins.  APO-E2 may also have a protective effect against AD.
Source: 
Genetically modified E.coli.             
Predicted MW:
Monomer, 34.4 kDa (301 amino acids)
AA Sequence: 
GPKVEQAVET EPEPELRQQT EWQSGQRWEL ALGRFWDYLR WVQTLSEQVQ EELLSSQVTQ ELRALMDETM KELKAYKSEL EEQLTPVAEE TRARLSKELQ AAQARLGADM EDVRGRLVQY RGEVQAMLGQ STEELRVRLA SHLRKLRKRL LRDADDLQKR LAVYQAGARE GAERGLSAIR ERLGPLVEQG RVRAATVGSL AGQPLQERAQ AWGERLRARM EEMGSRTRDR LDEVKEQVAE VRAKLEEQAQ QIRLQAEAFQ ARLKSWFEPL VEDMQRQWAG LVEKVQAAVG TSAAPVPSDN H
Formulation: 
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 0.5 mM DTT, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Specification

Method of Determination

Acceptance Criteria

Purity

Reducing and Non-Reducing SDS PAGE

≥90%

Endotoxin

Kinetic LAL

≤5 EUs/µg

Biological Activity

No biological activity data is available at this time

No biological activity data is available at this time
 
Preparation and Storage
Country of Origin:  USA        Shipping:  Room temperature             
Storage Prior to Reconstitution:  -20°C
Product Reconstitution:  Sterile water at 0.1 mg/mL
Instructions:  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Animal-Free Mg: 1 mg, Animal-Free Mini: 100 ug, Animal-Free Std.: 250 ug, Animal-Free Value: 500 ug, Mg: 1 mg, Mini: 100 ug, Std.: 250 ug, Value: 500 ug

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