Description

Accession/Uniprot Number: P02649 VAR_000652           
Description:  Apolipoprotein E (APO-E) is a chylomicron lipoprotein that is necessary for the metabolism of lipoproteins and lipid transport.  The APO-E gene has three alleles, termed APO-E2, APO-E3, and APO-E4.  The APO-E allelic proteins differ by only one or two amino acids, but have different biological structures and functions.  APO-E3 is the most common and neutral allele.  The APO-E4 allele is associated with an increased risk for Alzheimer’s Disease (AD) and coronary artery disease (CAD).  The APO-E4 protein morphology decreases the ability of APO-E4 to clear beta-amyloid protein from the brain, resulting in AD progression.  The APO-E2 allele is associated with type III hyperlipoproteinemia, which is characterized by defects in the clearance of plasma lipoproteins.  APO-E2 may also have a protective effect against AD.
Source:  Genetically modified E.coli.             
Predicted MW: Monomer, 34.4 kDa (301 amino acids)
AA Sequence:  GPKVEQAVET EPEPELRQQT EWQSGQRWEL ALGRFWDYLR WVQTLSEQVQ EELLSSQVTQ ELRALMDETM KELKAYKSEL EEQLTPVAEE TRARLSKELQ AAQARLGADM EDVRGRLVQY RGEVQAMLGQ STEELRVRLA SHLRKLRKRL LRDADDLQKR LAVYQAGARE GAERGLSAIR ERLGPLVEQG RVRAATVGSL AGQPLQERAQ AWGERLRARM EEMGSRTRDR LDEVKEQVAE VRAKLEEQAQ QIRLQAEAFQ ARLKSWFEPL VEDMQRQWAG LVEKVQAAVG TSAAPVPSDN H
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 0.5 mM DTT, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

Expiration Date:                      
12 months from date of receipt when stored at -20°C to -80°C as supplied.
1 month when stored at 4°C after reconstituting as directed.
3 months when stored at -20°C to -80°C after reconstituting as directed.

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