Shenandoah Biotech Logo

Human AREG

Human AREG

Part Number: 100-206

Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.‚AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR).‚AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium.

 

$67.00$1,716.00

Clear

Description

Alternate Names:  AR, AREG, Colorectum cell-derived growth factor, CRDGF             Accession Number: P15514
Description:  Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.  AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR).  AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis. In a cancer context, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the Hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia.
Source:  Genetically modified E.coli.
Predicted MW:  Monomer, 10.1 kDa (with 87 amino acids)
AA Sequence:  SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMK
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 

Specification Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS-PAGE ≥ 95%
Endotoxin Kinetic LAL (50% confidence) ≤ 1 EUs/µg
Biological Activity 3T3 Cell Proliferation ED50 ≤ 20 ng/mL


Preparation and Storage

Country of Origin:  USA         Shipping:  Room temperature

Storage Prior to Reconstitution:  -20°C

Product Reconstitution:  Sterile water at 0.1 mg/mL

Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.


Expiration Date:                      

12 months from date of receipt when stored at -20°C to -80°C as supplied.

1 month when stored at 4°C after reconstituting as directed.

3 months when stored at -20°C to -80°C after reconstituting as directed.

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Animal-Free Mg: 1 mg, Animal-Free Midig: 500 ug, Animal-Free Mini: 10 ug, Animal-Free Std.: 50 ug, Animal-Free Value: 100 ug, Mg: 1 mg, Midig: 500 ug, Mini: 10 ug, Std.: 50 ug, Value: 100 ug

Reviews

There are no reviews yet.

Be the first to review “Human AREG”