Description

Alternate Names:  GDGF, ODGF                   Accession Number: XP_005606703  
Description:  Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis.  PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling.  PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells.  PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues.  PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB).  The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β. 
Source:  Genetically modified E.coli. 
Predicted MW:  Dimer, 24.8 kDa (with 110/220 amino acids)
AA Sequence:  MSLGSLAVAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRHVQ CRPTQVQLRP VQVRKIEIVR KKPTFKKATV TLEDHLACKC ETVGAARPVT
Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Product Specifications*
*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements. 

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