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CTGrade rh FLT-3 Ligand

CTGrade rh FLT-3 Ligand

Part Number: 500-03

Containing no animal-derived materials, CTGrade rh Flt3-Ligand (FLT-3L) is produced in E. coli, is Beta Lactam-free, and manufactured by Shenandoah Biotechnology, Inc. in an ISO 9001:2015 certified facility that follows cGMP guidelines. CTGrade interleukins and growth factors are designed to support basic, translational, and clinical research, as well as commercial applications.*

$1,095.00$6,750.00

Description

Containing no animal-derived materials, CTGrade rh FLT-3 Ligand (FLT-3L) is produced in E. coli, is Beta Lactam-free, and manufactured by Shenandoah Biotechnology, Inc. in an ISO 9001:2015 certified facility that follows cGMP guidelines. CTGrade interleukins and growth factors are designed to support basic, translational, and clinical research, as well as commercial applications.*

● Extremely low endotoxin levels
● High biological activity verified by relevant bioactivity assay
● Carrier-free protein
● Available quantities: 50 µg, 100 µg, and 1 mg; custom sizes and packaging available

FLT-3L is a growth factor that regulates proliferation of early hematopoietic cells. FLT-3 Ligand binds to cells expressing the tyrosine kinase receptor FLT-3. FLT-3 Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, FLT-3 Ligand exerts no activity on mast cells. Multiple isoforms of FLT-3 Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. CTGrade rh FLT-3 Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

Technical Specifications**
Alternate Names: Fms-like tyrosine kinase 3 ligand, Flt3L
Accession Number: P49771
AA Sequence: TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
Purity: ≥ 97% by SDS-PAGE
Predicted Molecular Mass: 17.6 kDa
Formulation: 10 mM Sodium Phosphate, 50 mM Sodium Chloride, pH 7.5
Product Reconstitution: Sterile water at 0.1 mg/mL
Endotoxin level: ≤ 0.1 EU/ug
Activity: The ED50, as determined by the dose-dependent stimulation of the proliferation of human AML5 cells, is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg
Host Cell DNA: ≤ 10 pg/mL
Host Cell Protein: ≤ 30 ng/ml
Sterility: No growth
Country of Origin: USA

Storage: Store at -20°C in a non-defrosting freezer. Transportation temperature is 2-8°C.

Shelf Life: The lyophilized product is stable for 36 months from the date of manufacture; 12 months from date of receipt when stored at -20° C to -80° C as supplied, 1 month when stored at 4°C after reconstituting as directed, and 3 months when stored at -20°C to -80°C after reconstituted as directed. Avoid repeated freeze-thaw cycles.

*For research use or further manufacturing and in ex vivo cell therapy applications.
**Lot-specific values for the following specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Mg: 1mg, Mini: 50 ug, Std: 100ug

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