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CTGrade Recombinant Human IL-7

CTGrade Recombinant Human IL-7

Part Number: 500-07

CTGrade interleukins and growth factors are  signaling molecules that induce various cell functions or phenotypic changes and are used to stimulate and promote adaptive cellular immunity and tolerance with T cells.

CTGrade rh IL-7 promotes the stimulation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells.

CTGrade interleukins and growth factors are designed to support basic, translational, and clinical research, as well as commercial applications.

$1,112.00$7,182.00

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Description

CTGrade rh IL-7 is a human recombinant protein containing no animal-derived materials, is ≥ 97% pure, produced in E. coli, is Beta-lactam-free, and manufactured by Shenandoah in an ISO 9001:2015 certified facility that follows cGMP guidelines. CTGrade interleukins and growth factors are designed to support basic, translational, and clinical research, as well as commercial applications.**

● Extremely low endotoxin levels
● High biological activity verified by relevant bioactivity assay
● Carrier-free protein
● Available quantities: 50 µg, 100 µg, and 1 mg; custom sizes and packaging available

IL-7 promotes the stimulation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7 along with IL-2,15, and 21 is a member of the common gamma (γc) chain cytokine family. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through its (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. IL-7 in combination with IL-15 has been shown to promote favorable phenotypes in adoptive cellular therapies such as CAR T cell therapy.

Technical Specifications***
● Alternate Names: Lymphopoietin 1 (LP-1), pre-B cell Factor
● Accession Number: P13232
● AA Sequence: MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
● Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses
● Predicted Molecular Mass: Monomer, 17.5 kDa (153 aa)
● Formulation: 10 mM NaP, pH 7.5
● Product Reconstitution: Reconstitute at 0.1 mg/mL with Water
● Endotoxin level: <0.1 EU per 1 μg of the protein by the USP 85/ EP2.6.14 method
● Activity:
o Measured in a cell proliferation using a Mouse 2e8 cell proliferation assay
o The ED50 for this effect is ED50 ≤1 ng/mL
● Host Cell DNA: ≤ 10 ng/mL by RT-PCR
● Host Cell Protein: ≤ 30 ng/mL by ELISA
● Sterility: Negative on growth by USP 71/EP2.6.1
● Country of Origin: USA

Storage: Store at -20°C in a non-defrosting freezer. Transportation temperature is 2-8°C.
Shelf Life: The lyophilized product is stable for 36 months from the date of manufacture; 12 months from date of receipt when stored at -20° C to -80° C as supplied, 1 month when stored at 4°C after reconstituting as directed, and 3 months when stored at -20°C to -80°C after reconstituted as directed. Avoid repeated freeze-thaw cycles.

*Containing no animal-derived materials
**For research use or further manufacturing and in ex vivo cell therapy applications.
***Lot-specific values for the following specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Mg: 1mg, Mini: 50 ug, Std: 100ug

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