CTG Human IL-2

CTG Human IL-2

Part Number: 500-01

Interleukin-2 has essential roles in promoting adaptive cellular immunity and tolerance, primarily via its direct effects on T cells. The major source of IL-2 is from activated CD4+ or activated CD8+ T cells. Interleukin-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.  In addition, IL-2 stimulates regulatory T cell development indicating a critical role in the prevention of autoimmunity. Taken together, IL-2 is a indispensable growth factor for immune system homeostasis.

 

Shenandoah Biotechnology’s CTG™ Recombinant Human IL-2 is manufactured to the highest quality standard within the industry.  Rigorous quality control procedures ensure lot-to-lot consistency providing reproducibility in downstream cell culture processes.  The release of CTG™ IL-2 and future releases in the CTG™ product line from Shenandoah Biotechnology will enhance the development of cell-based therapies within the biopharmaceutical industry.

 

For research use or further manufacturing and in ex vivo cell therapy applications. Shenandoah’s CTG GMP grade recombinant proteins are not for Human use in direct in vivo applications or for direct clinical use as a drug, therapeutic, biologic or medical devices.

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Description

Alternate Names:T cell growth factor, TCGF, Aldesleukin

Accession Number: P60568

Description:Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.‚IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Source:Genetically modified E.coli.

Predicted MW: Monomer, 15.5 kDa (134 aa)

AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN‚ RWITFSQSII STLT

Formulation:Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*

*Lot-specific values for the following specifications are supplied with each product on its corresponding COA.‚The values provided here are minimum expected values to pass internal requirements.‚ 

TEST METHOD SPECIFICATION RESULT
‚ 

APPEARANCE

‚ 

VISUAL

White to off-white powder, without foreign particles ‚ 

Pass

PURITY Coomassie Staining Purity > 95% Pass
RETENTION TIME

(Peak integration)

HPLC 20.25-21.75 minutes Pass
CELL BASED BIOACTIVITY CTLL-2 Cell Proliferation ED50 ¢€°¤ 3 ng/L 0.031 ng/mL
HOST CELL PROTEIN ELISA < 30 ng/mL Pass
HOST CELL DNA RT-PCR ¢€°¤10 pg/mL Pass
STERILITY USP <71>/ EP 2.6.1 Negative for growth Pass
‚ 

MYCOPLASMA

Mycoplasma testing by PCR ‚ 

Negative

‚ 

Pass

ENDOTOXIN LEVEL USP <85>/ EP 2.6.14 <0.01 EUs/ug <0.01 EUs/ug
IDENTITY
‚ 

LC-MS/MS

MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFSQSII STLT ‚ 

Pass

WESTERN BLOT The sample and the standard present similar band patterns ‚ 

Pass

 

**** International Units: The specific activity of Human IL-2 is approximately‚ 1.8 x 10^4‚ IU/Ž¼g, which is calibrated against recombinant human IL-2 WHO International Standard (NIBSC code: 86/500).

Country of Origin:USA Shipping:2-8 Degrees 

Storage Prior to Reconstitution:-20‚°C

Product Reconstitution:Sterile 10 mM HCl at 0.1 mg/mL

Instructions:Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80‚°C and avoid repeat freeze thaws.

Expiration Date:

12 months from date of receipt when stored at -20‚°C to -80‚°C as supplied.

1 month when stored at 4‚°C after reconstituting as directed.

3 months when stored at -20‚°C to -80‚°C after reconstituting as directed. 

For research use or further manufacturing and in ex vivo cell therapy applications. Shenandoah¢‚¬„¢s CTG¢€ž¢ GMP grade recombinant proteins are not for Human use in direct in vivo applications or for direct clinical use as a drug, therapeutic, biologic or medical devices.

To receive more information or a bulk quote, email us at quotes@shenandoah-bt.com.

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
Select size

Mg: 1mg, Mini: 50 ug, Std: 100ug

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