Canine IL-4

Canine IL-4

Part Number: 400-09

Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naƒ¯ve helper T cells to differentiate into type 2 T helper (Th2) cells.‚Th2 cells subsequently produce more IL-4 in a positive feedback loop.‚IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells.‚IL-4 binds the IL-4RŽ± receptor to activate STAT6 signaling.

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Description

Alternate Names:‚B-cell stimulatory factor-1, BSF-1, BCDF, BCGF
Accession Number: O77762

Description:‚Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naƒ¯ve helper T cells to differentiate into type 2 T helper (Th2) cells.‚Th2 cells subsequently produce more IL-4 in a positive feedback loop.‚IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells.‚IL-4 binds the IL-4RŽ± receptor to activate STAT6 signaling.

Source: ‚ Genetically modified E.coli.

Predicted MW:‚Monomer, 12.9 kDa (with 109 amino acids)

AA Sequence:‚MHNFNITIKE IIKMLNILTA RNDSCMELTV KDVFTAPKNT SDKEIFCRAA TVLRQIYTHN CSNRYLRGLY RNLSSMANKT CSMNEIKKST LKDFLERLKV IMQKKYYRH

Formulation:‚Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Product Specifications*

*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA.‚

Specification Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS-PAGE ¢€°¥95%
Endotoxin Kinetic LAL (50% confidence) ¢€°¤ 1 EUs/‚µg
Biological Activity TF-1 cell proliferation ED50 ¢€°¤ 25 ng/mL

Preparation and Storage

Country of Origin:‚USA ‚ ‚ ‚ ‚ ‚ ‚ ‚Shipping:‚Room temperature

Storage Prior to Reconstitution:‚-20‚°C

Product Reconstitution:‚Sterile water at 0.1 mg/mL

Instructions:‚Centrifuge vial before opening.‚Suspend the product by gently pipetting the above recommended solution down the sides of the vial.‚DO NOT VORTEX.‚Allow several minutes for complete reconstitution.‚For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80‚°C and avoid repeat freeze thaws.

Expiration Date‚‚‚‚‚‚‚‚‚‚‚‚ 

12 months from date of receipt when stored at -20‚°C to -80‚°C as supplied.

1 month when stored at 4‚°C after reconstituting as directed.

3 months when stored at -20‚°C to -80‚°C after reconstituting as directed.

To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

Part Number: Other Terms:

Additional information

Dimensions 1 × 1 × 1 cm
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Animal-Free Mg: 1 mg, Animal-Free Midgi: 500 ug, Animal-Free Mini: 5 ug, Animal-Free Std: 25 ug, Animal-Free Value: 100 ug, Mg: 1 mg, Midgi: 500 ug, Mini: 5 ug, Std.: 25 ug, Value: 100 ug

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