Description:‚Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naƒ¯ve helper T cells to differentiate into type 2 T helper (Th2) cells.‚Th2 cells subsequently produce more IL-4 in a positive feedback loop.‚IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells.‚IL-4 binds the IL-4RŽ± receptor to activate STAT6 signaling.
Source: ‚ Genetically modified E.coli.
Predicted MW:‚Monomer, 12.9 kDa (with 109 amino acids)
AA Sequence:‚MHNFNITIKE IIKMLNILTA RNDSCMELTV KDVFTAPKNT SDKEIFCRAA TVLRQIYTHN CSNRYLRGLY RNLSSMANKT CSMNEIKKST LKDFLERLKV IMQKKYYRH
Formulation:‚Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA.‚
|Specification||Method of Determination||Acceptance Criteria|
|Purity||Reducing and Non-Reducing SDS-PAGE||¢€°¥95%|
|Endotoxin||Kinetic LAL (50% confidence)||¢€°¤ 1 EUs/‚µg|
|Biological Activity||TF-1 cell proliferation||ED50 ¢€°¤ 25 ng/mL|
Preparation and Storage
Country of Origin:‚USA ‚ ‚ ‚ ‚ ‚ ‚ ‚Shipping:‚Room temperature
Storage Prior to Reconstitution:‚-20‚°C
Product Reconstitution:‚Sterile water at 0.1 mg/mL
Instructions:‚Centrifuge vial before opening.‚Suspend the product by gently pipetting the above recommended solution down the sides of the vial.‚DO NOT VORTEX.‚Allow several minutes for complete reconstitution.‚For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80‚°C and avoid repeat freeze thaws.
12 months from date of receipt when stored at -20‚°C to -80‚°C as supplied.
1 month when stored at 4‚°C after reconstituting as directed.
3 months when stored at -20‚°C to -80‚°C after reconstituting as directed.
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