Canine IL-2

Canine IL-2

Part Number: 400-11

Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.‚IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation.‚IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

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Description

Alternate Names:  T cell growth factor, TCGF, Aldesleukin
Accession Number: Q29416 Description:  Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation.  IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages. Source:  Genetically modified E.coli. Predicted MW:  Monomer, 15.6 kDa (with 136 amino acids) AA Sequence:  MAPITSSSTK ETEQQMEQLL LDLQLLLNGV NNYENPQLSR MLTFKFYTPK KATEFTHLQC LAEELKNLEE VLGLPQSKNV HLTDTKELIS NMNVTLLKLK GSETSYNCEY DDETATITEF LNKWITFSQS IFSTLT Formulation:  Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 20 mM sodium bicarbonate,     pH 8.5
Product Specifications* *Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA. 
Specification Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS-PAGE ≥95%
Endotoxin Kinetic LAL (50% confidence) ≤ 1 EUs/µg
Biological Activity CTLL-2 cell proliferation ED50 ≤ 5 ng/mL
Preparation and Storage Country of Origin:  USA         Shipping:  Room temperature Storage Prior to Reconstitution:  -20°C Product Reconstitution:  Sterile 10 mM sodium bicarbonate, pH 8.5 at 0.1 mg/mL Instructions:  Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Expiration Date                        12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!            To receive more information or for a bulk quote, email us at quotes@shenandoah-bt.com.

Additional information

Dimensions 1 × 1 × 1 cm
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Animal-Free Mg: 1 mg, Animal-Free Midgi: 500 ug, Animal-Free Mini: 5 ug, Animal-Free Std: 25 ug, Animal-Free Value: 100 ug, Mg: 1 mg, Midgi: 500 ug, Mini: 5 ug, Std.: 25 ug, Value: 100 ug

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