Alternate Names:‚CSF-2, Pluripoietin-Ž±, MGI-1GM‚‚ ‚‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚Accession Number: P48749
Description:‚Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells.‚GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells.‚GM-CSF promotes immune system development and regulates neutrophil function during infection.
Source: ‚ Genetically modified E.coli.
Predicted MW:‚Monomer, 14.4 kDa (with 128 amino acids)
AA Sequence:‚MAPTRSPTLV TRPSQHVDAI QEALSLLNNS NDVTAVMNKA VKVVSEVFDP EGPTCLETRL QLYKEGLQGS LTSLKNPLTM MANHYKQHCP PTPESPCATQ NINFKSFKEN LKDFLFNIPF DCWKPVKK
Formulation:‚Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
*Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA.‚
|Specification||Method of Determination||Acceptance Criteria|
|Purity||Reducing and Non-Reducing SDS-PAGE||¢€°¥ 95%|
|Endotoxin||Kinetic LAL (50% confidence)||¢€°¤ 1 EUs/‚µg|
|Biological Activity||TF-1 cell proliferation||‚ ED50 ¢€°¤ 15 ng/mL|
Preparation and Storage
Country of Origin:‚USA
Shipping:‚Room temperature‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚Storage Prior to Reconstitution:‚-20‚°C
Product Reconstitution:‚Sterile water at 0.1 mg/mL
Instructions:‚Centrifuge vial before opening.‚Suspend the product by gently pipetting the above recommended solution down the sides of the vial.‚DO NOT VORTEX.‚Allow several minutes for complete reconstitution.‚For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80‚°C and avoid repeat freeze thaws.
12 months from date of receipt when stored at -20‚°C to -80‚°C as supplied.
1 month when stored at 4‚°C after reconstituting as directed.
3 months when stored at -20‚°C to -80‚°C after reconstituting as directed.
THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚ ‚
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