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Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, because the uterine immune environment has to tolerate the semi-allogeneic fetus and allow adequate trophoblast invasion.

 

Read the report by Dr. Renate van der Molen in the September 29, 2020 issue of Cell Reports entitled, “Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus”.

 

 

Highlights

• B cells obtained from the fetal-maternal interface gain memory during gestation

• Unsupervised analysis shows B cell subsets with marker expression unique to the uterus

• Decidual B cells are able to secrete IL-10

• Clusters of decidual B cells also contain T cells, including Foxp3pos T cells

 

Read the article here!

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